Recurrent PTPRB and PLCG1 mutations in angiosarcoma
Identifieur interne : 002589 ( Main/Exploration ); précédent : 002588; suivant : 002590Recurrent PTPRB and PLCG1 mutations in angiosarcoma
Auteurs : Sam Behjati [Royaume-Uni] ; Patrick S. Tarpey [Royaume-Uni] ; Helen Sheldon [Royaume-Uni] ; Inigo Martincorena [Royaume-Uni] ; Peter Van Loo [Royaume-Uni, Belgique] ; Gunes Gundem [Royaume-Uni] ; David C. Wedge [Royaume-Uni] ; Manasa Ramakrishna [Royaume-Uni] ; Susanna L. Cooke [Royaume-Uni] ; Nischalan Pillay [Royaume-Uni] ; Hans Kristian M. Vollan [Royaume-Uni, Norvège] ; Elli Papaemmanuil [Royaume-Uni] ; Hans Koss [Royaume-Uni] ; Tom D. Bunney [Royaume-Uni] ; Claire Hardy [Royaume-Uni] ; Olivia R. Joseph [Royaume-Uni] ; Sancha Martin [Royaume-Uni] ; Laura Mudie [Royaume-Uni] ; Adam Butler [Royaume-Uni] ; Jon W. Teague [Royaume-Uni] ; Meena Patil [Royaume-Uni] ; Graham Steers [Royaume-Uni] ; Yu Cao [États-Unis] ; Curtis Gumbs [États-Unis] ; Davis Ingram [États-Unis] ; Alexander J. Lazar [États-Unis] ; Latasha Little [États-Unis] ; Harshad Mahadeshwar [États-Unis] ; Alexei Protopopov [États-Unis] ; Ghadah A. Al Sannaa [États-Unis] ; Sahil Seth [États-Unis] ; Xingzhi Song [États-Unis] ; Jiabin Tang [États-Unis] ; Jianhua Zhang [États-Unis] ; Vinod Ravi [États-Unis] ; Keila E. Torres [États-Unis] ; Bhavisha Khatri [Royaume-Uni] ; Dina Halai [Royaume-Uni] ; Ioannis Roxanis [Royaume-Uni] ; Daniel Baumhoer [Suisse] ; Roberto Tirabosco [Royaume-Uni] ; M Fernanda Amary [Royaume-Uni] ; Chris Boshoff [Royaume-Uni] ; Ultan Mcdermott [Royaume-Uni] ; Matilda Katan [Royaume-Uni] ; Michael R. Stratton [Royaume-Uni] ; P Andrew Futreal [Royaume-Uni, États-Unis] ; Adrienne M. Flanagan [Royaume-Uni] ; Adrian Harris [Royaume-Uni] ; Peter J. Campbell [Royaume-Uni]Source :
- Nature genetics [ 1061-4036 ] ; 2014.
Descripteurs français
- KwdFr :
- Analyse de séquence d'ARN, Analyse de variance, Cellules endothéliales de la veine ombilicale humaine, Données de séquences moléculaires, Exome (génétique), Facteur de croissance endothéliale vasculaire de type A (antagonistes et inhibiteurs), Humains, Hémangiosarcome (génétique), Hémangiosarcome (traitement médicamenteux), Interférence par ARN, Mutation (génétique), Néovascularisation pathologique (génétique), Néovascularisation pathologique (traitement médicamenteux), Phospholipase C gamma (génétique), Receptor-Like Protein Tyrosine Phosphatases, Class 3 (génétique), Séquence nucléotidique.
- MESH :
- antagonistes et inhibiteurs : Facteur de croissance endothéliale vasculaire de type A.
- génétique : Exome, Hémangiosarcome, Mutation, Néovascularisation pathologique, Phospholipase C gamma, Receptor-Like Protein Tyrosine Phosphatases, Class 3.
- traitement médicamenteux : Hémangiosarcome, Néovascularisation pathologique.
- Analyse de séquence d'ARN, Analyse de variance, Cellules endothéliales de la veine ombilicale humaine, Données de séquences moléculaires, Humains, Interférence par ARN, Séquence nucléotidique.
English descriptors
- KwdEn :
- Analysis of Variance, Base Sequence, Exome (genetics), Hemangiosarcoma (drug therapy), Hemangiosarcoma (genetics), Human Umbilical Vein Endothelial Cells, Humans, Molecular Sequence Data, Mutation (genetics), Neovascularization, Pathologic (drug therapy), Neovascularization, Pathologic (genetics), Phospholipase C gamma (genetics), RNA Interference, Receptor-Like Protein Tyrosine Phosphatases, Class 3 (genetics), Sequence Analysis, RNA, Vascular Endothelial Growth Factor A (antagonists & inhibitors).
- MESH :
- chemical , antagonists & inhibitors : Vascular Endothelial Growth Factor A.
- chemical , genetics : Phospholipase C gamma, Receptor-Like Protein Tyrosine Phosphatases, Class 3.
- drug therapy : Hemangiosarcoma, Neovascularization, Pathologic.
- genetics : Exome, Hemangiosarcoma, Mutation, Neovascularization, Pathologic.
- Analysis of Variance, Base Sequence, Human Umbilical Vein Endothelial Cells, Humans, Molecular Sequence Data, RNA Interference, Sequence Analysis, RNA.
Abstract
Angiosarcoma is an aggressive malignancy that arises spontaneously or secondarily to ionising radiation or chronic lymphoedema
Url:
DOI: 10.1038/ng.2921
PubMed: 24633157
PubMed Central: 4032873
Affiliations:
- Belgique, Norvège, Royaume-Uni, Suisse, États-Unis
- Angleterre, Angleterre de l'Est, Grand Londres, Oxfordshire
- Cambridge, Londres, Oxford
- University College de Londres, Université d'Oxford, Université de Cambridge
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Le document en format XML
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Jebsen Center for Breast Cancer Research, University of Oslo, N-0424 Oslo</wicri:regionArea><wicri:noRegion>N-0424 Oslo</wicri:noRegion></affiliation></author><author><name sortKey="Papaemmanuil, Elli" sort="Papaemmanuil, Elli" uniqKey="Papaemmanuil E" first="Elli" last="Papaemmanuil">Elli Papaemmanuil</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA</wicri:regionArea><wicri:noRegion>CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Koss, Hans" sort="Koss, Hans" uniqKey="Koss H" first="Hans" last="Koss">Hans Koss</name><affiliation wicri:level="4"><nlm:aff id="A9">Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London WC1E 6BT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London WC1E 6BT</wicri:regionArea><orgName type="university">University College de Londres</orgName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A10">Division of Molecular Structure, MRC-National Institute for Medical Research, Mill Hill, London NW7 1AA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Molecular Structure, MRC-National Institute for Medical Research, Mill Hill, London NW7 1AA</wicri:regionArea><wicri:noRegion>London NW7 1AA</wicri:noRegion></affiliation></author><author><name sortKey="Bunney, Tom D" sort="Bunney, Tom D" uniqKey="Bunney T" first="Tom D" last="Bunney">Tom D. Bunney</name><affiliation wicri:level="4"><nlm:aff id="A9">Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London WC1E 6BT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London WC1E 6BT</wicri:regionArea><orgName type="university">University College de Londres</orgName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Hardy, Claire" sort="Hardy, Claire" uniqKey="Hardy C" first="Claire" last="Hardy">Claire Hardy</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA</wicri:regionArea><wicri:noRegion>CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Joseph, Olivia R" sort="Joseph, Olivia R" uniqKey="Joseph O" first="Olivia R" last="Joseph">Olivia R. Joseph</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA</wicri:regionArea><wicri:noRegion>CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Martin, Sancha" sort="Martin, Sancha" uniqKey="Martin S" first="Sancha" last="Martin">Sancha Martin</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA</wicri:regionArea><wicri:noRegion>CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Mudie, Laura" sort="Mudie, Laura" uniqKey="Mudie L" first="Laura" last="Mudie">Laura Mudie</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA</wicri:regionArea><wicri:noRegion>CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Butler, Adam" sort="Butler, Adam" uniqKey="Butler A" first="Adam" last="Butler">Adam Butler</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA</wicri:regionArea><wicri:noRegion>CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Teague, Jon W" sort="Teague, Jon W" uniqKey="Teague J" first="Jon W" last="Teague">Jon W. Teague</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA</wicri:regionArea><wicri:noRegion>CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Patil, Meena" sort="Patil, Meena" uniqKey="Patil M" first="Meena" last="Patil">Meena Patil</name><affiliation wicri:level="1"><nlm:aff id="A11">Department of Pathology, John Radcliffe Hospital, Oxford, OX3 9DS, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Pathology, John Radcliffe Hospital, Oxford, OX3 9DS</wicri:regionArea><wicri:noRegion>OX3 9DS</wicri:noRegion></affiliation></author><author><name sortKey="Steers, Graham" sort="Steers, Graham" uniqKey="Steers G" first="Graham" last="Steers">Graham Steers</name><affiliation wicri:level="1"><nlm:aff id="A11">Department of Pathology, John Radcliffe Hospital, Oxford, OX3 9DS, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Pathology, John Radcliffe Hospital, Oxford, OX3 9DS</wicri:regionArea><wicri:noRegion>OX3 9DS</wicri:noRegion></affiliation></author><author><name sortKey="Cao, Yu" sort="Cao, Yu" uniqKey="Cao Y" first="Yu" last="Cao">Yu Cao</name><affiliation wicri:level="1"><nlm:aff id="A12">M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054</wicri:regionArea><wicri:noRegion>Texas 77054</wicri:noRegion></affiliation></author><author><name sortKey="Gumbs, Curtis" sort="Gumbs, Curtis" uniqKey="Gumbs C" first="Curtis" last="Gumbs">Curtis Gumbs</name><affiliation wicri:level="1"><nlm:aff id="A12">M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054</wicri:regionArea><wicri:noRegion>Texas 77054</wicri:noRegion></affiliation></author><author><name sortKey="Ingram, Davis" sort="Ingram, Davis" uniqKey="Ingram D" first="Davis" last="Ingram">Davis Ingram</name><affiliation wicri:level="1"><nlm:aff id="A12">M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054</wicri:regionArea><wicri:noRegion>Texas 77054</wicri:noRegion></affiliation></author><author><name sortKey="Lazar, Alexander J" sort="Lazar, Alexander J" uniqKey="Lazar A" first="Alexander J" last="Lazar">Alexander J. Lazar</name><affiliation wicri:level="1"><nlm:aff id="A12">M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054</wicri:regionArea><wicri:noRegion>Texas 77054</wicri:noRegion></affiliation></author><author><name sortKey="Little, Latasha" sort="Little, Latasha" uniqKey="Little L" first="Latasha" last="Little">Latasha Little</name><affiliation wicri:level="1"><nlm:aff id="A12">M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054</wicri:regionArea><wicri:noRegion>Texas 77054</wicri:noRegion></affiliation></author><author><name sortKey="Mahadeshwar, Harshad" sort="Mahadeshwar, Harshad" uniqKey="Mahadeshwar H" first="Harshad" last="Mahadeshwar">Harshad Mahadeshwar</name><affiliation wicri:level="1"><nlm:aff id="A12">M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054</wicri:regionArea><wicri:noRegion>Texas 77054</wicri:noRegion></affiliation></author><author><name sortKey="Protopopov, Alexei" sort="Protopopov, Alexei" uniqKey="Protopopov A" first="Alexei" last="Protopopov">Alexei Protopopov</name><affiliation wicri:level="1"><nlm:aff id="A12">M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054</wicri:regionArea><wicri:noRegion>Texas 77054</wicri:noRegion></affiliation></author><author><name sortKey="Al Sannaa, Ghadah A" sort="Al Sannaa, Ghadah A" uniqKey="Al Sannaa G" first="Ghadah A" last="Al Sannaa">Ghadah A. Al Sannaa</name><affiliation wicri:level="1"><nlm:aff id="A12">M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054</wicri:regionArea><wicri:noRegion>Texas 77054</wicri:noRegion></affiliation></author><author><name sortKey="Seth, Sahil" sort="Seth, Sahil" uniqKey="Seth S" first="Sahil" last="Seth">Sahil Seth</name><affiliation wicri:level="1"><nlm:aff id="A12">M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054</wicri:regionArea><wicri:noRegion>Texas 77054</wicri:noRegion></affiliation></author><author><name sortKey="Song, Xingzhi" sort="Song, Xingzhi" uniqKey="Song X" first="Xingzhi" last="Song">Xingzhi Song</name><affiliation wicri:level="1"><nlm:aff id="A12">M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054</wicri:regionArea><wicri:noRegion>Texas 77054</wicri:noRegion></affiliation></author><author><name sortKey="Tang, Jiabin" sort="Tang, Jiabin" uniqKey="Tang J" first="Jiabin" last="Tang">Jiabin Tang</name><affiliation wicri:level="1"><nlm:aff id="A12">M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054</wicri:regionArea><wicri:noRegion>Texas 77054</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Jianhua" sort="Zhang, Jianhua" uniqKey="Zhang J" first="Jianhua" last="Zhang">Jianhua Zhang</name><affiliation wicri:level="1"><nlm:aff id="A12">M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054</wicri:regionArea><wicri:noRegion>Texas 77054</wicri:noRegion></affiliation></author><author><name sortKey="Ravi, Vinod" sort="Ravi, Vinod" uniqKey="Ravi V" first="Vinod" last="Ravi">Vinod Ravi</name><affiliation wicri:level="1"><nlm:aff id="A12">M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054</wicri:regionArea><wicri:noRegion>Texas 77054</wicri:noRegion></affiliation></author><author><name sortKey="Torres, Keila E" sort="Torres, Keila E" uniqKey="Torres K" first="Keila E" last="Torres">Keila E. Torres</name><affiliation wicri:level="1"><nlm:aff id="A12">M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054</wicri:regionArea><wicri:noRegion>Texas 77054</wicri:noRegion></affiliation></author><author><name sortKey="Khatri, Bhavisha" sort="Khatri, Bhavisha" uniqKey="Khatri B" first="Bhavisha" last="Khatri">Bhavisha Khatri</name><affiliation wicri:level="1"><nlm:aff id="A5">Histopathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex, HA7 4LP, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Histopathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex, HA7 4LP</wicri:regionArea><wicri:noRegion>HA7 4LP</wicri:noRegion></affiliation></author><author><name sortKey="Halai, Dina" sort="Halai, Dina" uniqKey="Halai D" first="Dina" last="Halai">Dina Halai</name><affiliation wicri:level="1"><nlm:aff id="A5">Histopathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex, HA7 4LP, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Histopathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex, HA7 4LP</wicri:regionArea><wicri:noRegion>HA7 4LP</wicri:noRegion></affiliation></author><author><name sortKey="Roxanis, Ioannis" sort="Roxanis, Ioannis" uniqKey="Roxanis I" first="Ioannis" last="Roxanis">Ioannis Roxanis</name><affiliation wicri:level="1"><nlm:aff id="A11">Department of Pathology, John Radcliffe Hospital, Oxford, OX3 9DS, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Pathology, John Radcliffe Hospital, Oxford, OX3 9DS</wicri:regionArea><wicri:noRegion>OX3 9DS</wicri:noRegion></affiliation></author><author><name sortKey="Baumhoer, Daniel" sort="Baumhoer, Daniel" uniqKey="Baumhoer D" first="Daniel" last="Baumhoer">Daniel Baumhoer</name><affiliation wicri:level="1"><nlm:aff id="A13">Bone Tumour Reference Centre, Institute of Pathology, University Hospital Basel, Basel, Institute for Applied Cancer Science, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Bone Tumour Reference Centre, Institute of Pathology, University Hospital Basel, Basel, Institute for Applied Cancer Science</wicri:regionArea><wicri:noRegion>Institute for Applied Cancer Science</wicri:noRegion></affiliation></author><author><name sortKey="Tirabosco, Roberto" sort="Tirabosco, Roberto" uniqKey="Tirabosco R" first="Roberto" last="Tirabosco">Roberto Tirabosco</name><affiliation wicri:level="1"><nlm:aff id="A5">Histopathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex, HA7 4LP, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Histopathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex, HA7 4LP</wicri:regionArea><wicri:noRegion>HA7 4LP</wicri:noRegion></affiliation></author><author><name sortKey="Amary, M Fernanda" sort="Amary, M Fernanda" uniqKey="Amary M" first="M Fernanda" last="Amary">M Fernanda Amary</name><affiliation wicri:level="1"><nlm:aff id="A5">Histopathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex, HA7 4LP, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Histopathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex, HA7 4LP</wicri:regionArea><wicri:noRegion>HA7 4LP</wicri:noRegion></affiliation></author><author><name sortKey="Boshoff, Chris" sort="Boshoff, Chris" uniqKey="Boshoff C" first="Chris" last="Boshoff">Chris Boshoff</name><affiliation wicri:level="1"><nlm:aff id="A6">University College London Cancer Institute, Huntley Street, London, WC1E 6BT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University College London Cancer Institute, Huntley Street, London, WC1E 6BT</wicri:regionArea><wicri:noRegion>WC1E 6BT</wicri:noRegion></affiliation><affiliation><nlm:aff id="A14">Pfizer Oncology, 10555 Science Center Dr, La Jolla, CA, 92121</nlm:aff><wicri:noCountry code="subfield">92121</wicri:noCountry></affiliation></author><author><name sortKey="Mcdermott, Ultan" sort="Mcdermott, Ultan" uniqKey="Mcdermott U" first="Ultan" last="Mcdermott">Ultan Mcdermott</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA</wicri:regionArea><wicri:noRegion>CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Katan, Matilda" sort="Katan, Matilda" uniqKey="Katan M" first="Matilda" last="Katan">Matilda Katan</name><affiliation wicri:level="4"><nlm:aff id="A9">Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London WC1E 6BT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London WC1E 6BT</wicri:regionArea><orgName type="university">University College de Londres</orgName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Stratton, Michael R" sort="Stratton, Michael R" uniqKey="Stratton M" first="Michael R" last="Stratton">Michael R. Stratton</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA</wicri:regionArea><wicri:noRegion>CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Futreal, P Andrew" sort="Futreal, P Andrew" uniqKey="Futreal P" first="P Andrew" last="Futreal">P Andrew Futreal</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA</wicri:regionArea><wicri:noRegion>CB10 1SA</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A12">M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054</wicri:regionArea><wicri:noRegion>Texas 77054</wicri:noRegion></affiliation></author><author><name sortKey="Flanagan, Adrienne M" sort="Flanagan, Adrienne M" uniqKey="Flanagan A" first="Adrienne M" last="Flanagan">Adrienne M. Flanagan</name><affiliation wicri:level="1"><nlm:aff id="A5">Histopathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex, HA7 4LP, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Histopathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex, HA7 4LP</wicri:regionArea><wicri:noRegion>HA7 4LP</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">University College London Cancer Institute, Huntley Street, London, WC1E 6BT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University College London Cancer Institute, Huntley Street, London, WC1E 6BT</wicri:regionArea><wicri:noRegion>WC1E 6BT</wicri:noRegion></affiliation></author><author><name sortKey="Harris, Adrian" sort="Harris, Adrian" uniqKey="Harris A" first="Adrian" last="Harris">Adrian Harris</name><affiliation wicri:level="4"><nlm:aff id="A3">The Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, OX3 9DS, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, OX3 9DS</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A11">Department of Pathology, John Radcliffe Hospital, Oxford, OX3 9DS, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Pathology, John Radcliffe Hospital, Oxford, OX3 9DS</wicri:regionArea><wicri:noRegion>OX3 9DS</wicri:noRegion></affiliation></author><author><name sortKey="Campbell, Peter J" sort="Campbell, Peter J" uniqKey="Campbell P" first="Peter J" last="Campbell">Peter J. Campbell</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA</wicri:regionArea><wicri:noRegion>CB10 1SA</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A15">Department of Haematology, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, Addenbrooke’s Hospital, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A16">Department of Haematology, University of Cambridge, Hills Road, Cambridge, CB2 2XY, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, University of Cambridge, Hills Road, Cambridge, CB2 2XY</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24633157</idno><idno type="pmc">4032873</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032873</idno><idno type="RBID">PMC:4032873</idno><idno type="doi">10.1038/ng.2921</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">004709</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">004709</idno><idno type="wicri:Area/Pmc/Curation">004708</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">004708</idno><idno type="wicri:Area/Pmc/Checkpoint">001828</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001828</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">001622</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001622</idno><idno type="wicri:Area/PubMed/Curation">001622</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001622</idno><idno type="wicri:Area/PubMed/Checkpoint">001622</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001622</idno><idno type="wicri:Area/Ncbi/Merge">006426</idno><idno type="wicri:Area/Ncbi/Curation">006426</idno><idno type="wicri:Area/Ncbi/Checkpoint">006426</idno><idno type="wicri:Area/Main/Merge">002593</idno><idno type="wicri:Area/Main/Curation">002589</idno><idno type="wicri:Area/Main/Exploration">002589</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Recurrent <italic>PTPRB</italic> and <italic>PLCG1</italic> mutations in angiosarcoma</title><author><name sortKey="Behjati, Sam" sort="Behjati, Sam" uniqKey="Behjati S" first="Sam" last="Behjati">Sam Behjati</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA</wicri:regionArea><wicri:noRegion>CB10 1SA</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A2">Department of Paediatrics, University of Cambridge, Hills Road, Cambridge, CB2 2XY, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Paediatrics, University of Cambridge, Hills Road, Cambridge, CB2 2XY</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Tarpey, Patrick S" sort="Tarpey, Patrick S" uniqKey="Tarpey P" first="Patrick S" last="Tarpey">Patrick S. Tarpey</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA</wicri:regionArea><wicri:noRegion>CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Sheldon, Helen" sort="Sheldon, Helen" uniqKey="Sheldon H" first="Helen" last="Sheldon">Helen Sheldon</name><affiliation wicri:level="4"><nlm:aff id="A3">The Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, OX3 9DS, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, OX3 9DS</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Martincorena, Inigo" sort="Martincorena, Inigo" uniqKey="Martincorena I" first="Inigo" last="Martincorena">Inigo Martincorena</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA</wicri:regionArea><wicri:noRegion>CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Van Loo, Peter" sort="Van Loo, Peter" uniqKey="Van Loo P" first="Peter" last="Van Loo">Peter Van Loo</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA</wicri:regionArea><wicri:noRegion>CB10 1SA</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">Human Genome Laboratory, Department of Human Genetics, VIB and KU Leuven, B-3000 Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Human Genome Laboratory, Department of Human Genetics, VIB and KU Leuven, B-3000 Leuven</wicri:regionArea><wicri:noRegion>B-3000 Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Gundem, Gunes" sort="Gundem, Gunes" uniqKey="Gundem G" first="Gunes" last="Gundem">Gunes Gundem</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA</wicri:regionArea><wicri:noRegion>CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Wedge, David C" sort="Wedge, David C" uniqKey="Wedge D" first="David C" last="Wedge">David C. Wedge</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA</wicri:regionArea><wicri:noRegion>CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Ramakrishna, Manasa" sort="Ramakrishna, Manasa" uniqKey="Ramakrishna M" first="Manasa" last="Ramakrishna">Manasa Ramakrishna</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA</wicri:regionArea><wicri:noRegion>CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Cooke, Susanna L" sort="Cooke, Susanna L" uniqKey="Cooke S" first="Susanna L" last="Cooke">Susanna L. Cooke</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA</wicri:regionArea><wicri:noRegion>CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Pillay, Nischalan" sort="Pillay, Nischalan" uniqKey="Pillay N" first="Nischalan" last="Pillay">Nischalan Pillay</name><affiliation wicri:level="1"><nlm:aff id="A5">Histopathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex, HA7 4LP, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Histopathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex, HA7 4LP</wicri:regionArea><wicri:noRegion>HA7 4LP</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">University College London Cancer Institute, Huntley Street, London, WC1E 6BT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University College London Cancer Institute, Huntley Street, London, WC1E 6BT</wicri:regionArea><wicri:noRegion>WC1E 6BT</wicri:noRegion></affiliation></author><author><name sortKey="Vollan, Hans Kristian M" sort="Vollan, Hans Kristian M" uniqKey="Vollan H" first="Hans Kristian M" last="Vollan">Hans Kristian M. Vollan</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA</wicri:regionArea><wicri:noRegion>CB10 1SA</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A7">Department of Oncology, Oslo University Hospital, N-0310 Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Oncology, Oslo University Hospital, N-0310 Oslo</wicri:regionArea><wicri:noRegion>N-0310 Oslo</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">The K.G. Jebsen Center for Breast Cancer Research, University of Oslo, N-0424 Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>The K.G. Jebsen Center for Breast Cancer Research, University of Oslo, N-0424 Oslo</wicri:regionArea><wicri:noRegion>N-0424 Oslo</wicri:noRegion></affiliation></author><author><name sortKey="Papaemmanuil, Elli" sort="Papaemmanuil, Elli" uniqKey="Papaemmanuil E" first="Elli" last="Papaemmanuil">Elli Papaemmanuil</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA</wicri:regionArea><wicri:noRegion>CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Koss, Hans" sort="Koss, Hans" uniqKey="Koss H" first="Hans" last="Koss">Hans Koss</name><affiliation wicri:level="4"><nlm:aff id="A9">Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London WC1E 6BT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London WC1E 6BT</wicri:regionArea><orgName type="university">University College de Londres</orgName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A10">Division of Molecular Structure, MRC-National Institute for Medical Research, Mill Hill, London NW7 1AA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Molecular Structure, MRC-National Institute for Medical Research, Mill Hill, London NW7 1AA</wicri:regionArea><wicri:noRegion>London NW7 1AA</wicri:noRegion></affiliation></author><author><name sortKey="Bunney, Tom D" sort="Bunney, Tom D" uniqKey="Bunney T" first="Tom D" last="Bunney">Tom D. Bunney</name><affiliation wicri:level="4"><nlm:aff id="A9">Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London WC1E 6BT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London WC1E 6BT</wicri:regionArea><orgName type="university">University College de Londres</orgName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Hardy, Claire" sort="Hardy, Claire" uniqKey="Hardy C" first="Claire" last="Hardy">Claire Hardy</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA</wicri:regionArea><wicri:noRegion>CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Joseph, Olivia R" sort="Joseph, Olivia R" uniqKey="Joseph O" first="Olivia R" last="Joseph">Olivia R. Joseph</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA</wicri:regionArea><wicri:noRegion>CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Martin, Sancha" sort="Martin, Sancha" uniqKey="Martin S" first="Sancha" last="Martin">Sancha Martin</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA</wicri:regionArea><wicri:noRegion>CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Mudie, Laura" sort="Mudie, Laura" uniqKey="Mudie L" first="Laura" last="Mudie">Laura Mudie</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA</wicri:regionArea><wicri:noRegion>CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Butler, Adam" sort="Butler, Adam" uniqKey="Butler A" first="Adam" last="Butler">Adam Butler</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA</wicri:regionArea><wicri:noRegion>CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Teague, Jon W" sort="Teague, Jon W" uniqKey="Teague J" first="Jon W" last="Teague">Jon W. Teague</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA</wicri:regionArea><wicri:noRegion>CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Patil, Meena" sort="Patil, Meena" uniqKey="Patil M" first="Meena" last="Patil">Meena Patil</name><affiliation wicri:level="1"><nlm:aff id="A11">Department of Pathology, John Radcliffe Hospital, Oxford, OX3 9DS, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Pathology, John Radcliffe Hospital, Oxford, OX3 9DS</wicri:regionArea><wicri:noRegion>OX3 9DS</wicri:noRegion></affiliation></author><author><name sortKey="Steers, Graham" sort="Steers, Graham" uniqKey="Steers G" first="Graham" last="Steers">Graham Steers</name><affiliation wicri:level="1"><nlm:aff id="A11">Department of Pathology, John Radcliffe Hospital, Oxford, OX3 9DS, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Pathology, John Radcliffe Hospital, Oxford, OX3 9DS</wicri:regionArea><wicri:noRegion>OX3 9DS</wicri:noRegion></affiliation></author><author><name sortKey="Cao, Yu" sort="Cao, Yu" uniqKey="Cao Y" first="Yu" last="Cao">Yu Cao</name><affiliation wicri:level="1"><nlm:aff id="A12">M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054</wicri:regionArea><wicri:noRegion>Texas 77054</wicri:noRegion></affiliation></author><author><name sortKey="Gumbs, Curtis" sort="Gumbs, Curtis" uniqKey="Gumbs C" first="Curtis" last="Gumbs">Curtis Gumbs</name><affiliation wicri:level="1"><nlm:aff id="A12">M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054</wicri:regionArea><wicri:noRegion>Texas 77054</wicri:noRegion></affiliation></author><author><name sortKey="Ingram, Davis" sort="Ingram, Davis" uniqKey="Ingram D" first="Davis" last="Ingram">Davis Ingram</name><affiliation wicri:level="1"><nlm:aff id="A12">M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054</wicri:regionArea><wicri:noRegion>Texas 77054</wicri:noRegion></affiliation></author><author><name sortKey="Lazar, Alexander J" sort="Lazar, Alexander J" uniqKey="Lazar A" first="Alexander J" last="Lazar">Alexander J. Lazar</name><affiliation wicri:level="1"><nlm:aff id="A12">M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054</wicri:regionArea><wicri:noRegion>Texas 77054</wicri:noRegion></affiliation></author><author><name sortKey="Little, Latasha" sort="Little, Latasha" uniqKey="Little L" first="Latasha" last="Little">Latasha Little</name><affiliation wicri:level="1"><nlm:aff id="A12">M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054</wicri:regionArea><wicri:noRegion>Texas 77054</wicri:noRegion></affiliation></author><author><name sortKey="Mahadeshwar, Harshad" sort="Mahadeshwar, Harshad" uniqKey="Mahadeshwar H" first="Harshad" last="Mahadeshwar">Harshad Mahadeshwar</name><affiliation wicri:level="1"><nlm:aff id="A12">M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054</wicri:regionArea><wicri:noRegion>Texas 77054</wicri:noRegion></affiliation></author><author><name sortKey="Protopopov, Alexei" sort="Protopopov, Alexei" uniqKey="Protopopov A" first="Alexei" last="Protopopov">Alexei Protopopov</name><affiliation wicri:level="1"><nlm:aff id="A12">M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054</wicri:regionArea><wicri:noRegion>Texas 77054</wicri:noRegion></affiliation></author><author><name sortKey="Al Sannaa, Ghadah A" sort="Al Sannaa, Ghadah A" uniqKey="Al Sannaa G" first="Ghadah A" last="Al Sannaa">Ghadah A. Al Sannaa</name><affiliation wicri:level="1"><nlm:aff id="A12">M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054</wicri:regionArea><wicri:noRegion>Texas 77054</wicri:noRegion></affiliation></author><author><name sortKey="Seth, Sahil" sort="Seth, Sahil" uniqKey="Seth S" first="Sahil" last="Seth">Sahil Seth</name><affiliation wicri:level="1"><nlm:aff id="A12">M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054</wicri:regionArea><wicri:noRegion>Texas 77054</wicri:noRegion></affiliation></author><author><name sortKey="Song, Xingzhi" sort="Song, Xingzhi" uniqKey="Song X" first="Xingzhi" last="Song">Xingzhi Song</name><affiliation wicri:level="1"><nlm:aff id="A12">M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054</wicri:regionArea><wicri:noRegion>Texas 77054</wicri:noRegion></affiliation></author><author><name sortKey="Tang, Jiabin" sort="Tang, Jiabin" uniqKey="Tang J" first="Jiabin" last="Tang">Jiabin Tang</name><affiliation wicri:level="1"><nlm:aff id="A12">M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054</wicri:regionArea><wicri:noRegion>Texas 77054</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Jianhua" sort="Zhang, Jianhua" uniqKey="Zhang J" first="Jianhua" last="Zhang">Jianhua Zhang</name><affiliation wicri:level="1"><nlm:aff id="A12">M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054</wicri:regionArea><wicri:noRegion>Texas 77054</wicri:noRegion></affiliation></author><author><name sortKey="Ravi, Vinod" sort="Ravi, Vinod" uniqKey="Ravi V" first="Vinod" last="Ravi">Vinod Ravi</name><affiliation wicri:level="1"><nlm:aff id="A12">M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054</wicri:regionArea><wicri:noRegion>Texas 77054</wicri:noRegion></affiliation></author><author><name sortKey="Torres, Keila E" sort="Torres, Keila E" uniqKey="Torres K" first="Keila E" last="Torres">Keila E. Torres</name><affiliation wicri:level="1"><nlm:aff id="A12">M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054</wicri:regionArea><wicri:noRegion>Texas 77054</wicri:noRegion></affiliation></author><author><name sortKey="Khatri, Bhavisha" sort="Khatri, Bhavisha" uniqKey="Khatri B" first="Bhavisha" last="Khatri">Bhavisha Khatri</name><affiliation wicri:level="1"><nlm:aff id="A5">Histopathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex, HA7 4LP, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Histopathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex, HA7 4LP</wicri:regionArea><wicri:noRegion>HA7 4LP</wicri:noRegion></affiliation></author><author><name sortKey="Halai, Dina" sort="Halai, Dina" uniqKey="Halai D" first="Dina" last="Halai">Dina Halai</name><affiliation wicri:level="1"><nlm:aff id="A5">Histopathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex, HA7 4LP, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Histopathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex, HA7 4LP</wicri:regionArea><wicri:noRegion>HA7 4LP</wicri:noRegion></affiliation></author><author><name sortKey="Roxanis, Ioannis" sort="Roxanis, Ioannis" uniqKey="Roxanis I" first="Ioannis" last="Roxanis">Ioannis Roxanis</name><affiliation wicri:level="1"><nlm:aff id="A11">Department of Pathology, John Radcliffe Hospital, Oxford, OX3 9DS, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Pathology, John Radcliffe Hospital, Oxford, OX3 9DS</wicri:regionArea><wicri:noRegion>OX3 9DS</wicri:noRegion></affiliation></author><author><name sortKey="Baumhoer, Daniel" sort="Baumhoer, Daniel" uniqKey="Baumhoer D" first="Daniel" last="Baumhoer">Daniel Baumhoer</name><affiliation wicri:level="1"><nlm:aff id="A13">Bone Tumour Reference Centre, Institute of Pathology, University Hospital Basel, Basel, Institute for Applied Cancer Science, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Bone Tumour Reference Centre, Institute of Pathology, University Hospital Basel, Basel, Institute for Applied Cancer Science</wicri:regionArea><wicri:noRegion>Institute for Applied Cancer Science</wicri:noRegion></affiliation></author><author><name sortKey="Tirabosco, Roberto" sort="Tirabosco, Roberto" uniqKey="Tirabosco R" first="Roberto" last="Tirabosco">Roberto Tirabosco</name><affiliation wicri:level="1"><nlm:aff id="A5">Histopathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex, HA7 4LP, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Histopathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex, HA7 4LP</wicri:regionArea><wicri:noRegion>HA7 4LP</wicri:noRegion></affiliation></author><author><name sortKey="Amary, M Fernanda" sort="Amary, M Fernanda" uniqKey="Amary M" first="M Fernanda" last="Amary">M Fernanda Amary</name><affiliation wicri:level="1"><nlm:aff id="A5">Histopathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex, HA7 4LP, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Histopathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex, HA7 4LP</wicri:regionArea><wicri:noRegion>HA7 4LP</wicri:noRegion></affiliation></author><author><name sortKey="Boshoff, Chris" sort="Boshoff, Chris" uniqKey="Boshoff C" first="Chris" last="Boshoff">Chris Boshoff</name><affiliation wicri:level="1"><nlm:aff id="A6">University College London Cancer Institute, Huntley Street, London, WC1E 6BT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University College London Cancer Institute, Huntley Street, London, WC1E 6BT</wicri:regionArea><wicri:noRegion>WC1E 6BT</wicri:noRegion></affiliation><affiliation><nlm:aff id="A14">Pfizer Oncology, 10555 Science Center Dr, La Jolla, CA, 92121</nlm:aff><wicri:noCountry code="subfield">92121</wicri:noCountry></affiliation></author><author><name sortKey="Mcdermott, Ultan" sort="Mcdermott, Ultan" uniqKey="Mcdermott U" first="Ultan" last="Mcdermott">Ultan Mcdermott</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA</wicri:regionArea><wicri:noRegion>CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Katan, Matilda" sort="Katan, Matilda" uniqKey="Katan M" first="Matilda" last="Katan">Matilda Katan</name><affiliation wicri:level="4"><nlm:aff id="A9">Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London WC1E 6BT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London WC1E 6BT</wicri:regionArea><orgName type="university">University College de Londres</orgName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Stratton, Michael R" sort="Stratton, Michael R" uniqKey="Stratton M" first="Michael R" last="Stratton">Michael R. Stratton</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA</wicri:regionArea><wicri:noRegion>CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Futreal, P Andrew" sort="Futreal, P Andrew" uniqKey="Futreal P" first="P Andrew" last="Futreal">P Andrew Futreal</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA</wicri:regionArea><wicri:noRegion>CB10 1SA</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A12">M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>M. D. Anderson Cancer Center, The University of Texas, 1901 East Road, Houston, Texas 77054</wicri:regionArea><wicri:noRegion>Texas 77054</wicri:noRegion></affiliation></author><author><name sortKey="Flanagan, Adrienne M" sort="Flanagan, Adrienne M" uniqKey="Flanagan A" first="Adrienne M" last="Flanagan">Adrienne M. Flanagan</name><affiliation wicri:level="1"><nlm:aff id="A5">Histopathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex, HA7 4LP, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Histopathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex, HA7 4LP</wicri:regionArea><wicri:noRegion>HA7 4LP</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">University College London Cancer Institute, Huntley Street, London, WC1E 6BT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University College London Cancer Institute, Huntley Street, London, WC1E 6BT</wicri:regionArea><wicri:noRegion>WC1E 6BT</wicri:noRegion></affiliation></author><author><name sortKey="Harris, Adrian" sort="Harris, Adrian" uniqKey="Harris A" first="Adrian" last="Harris">Adrian Harris</name><affiliation wicri:level="4"><nlm:aff id="A3">The Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, OX3 9DS, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, OX3 9DS</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A11">Department of Pathology, John Radcliffe Hospital, Oxford, OX3 9DS, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Pathology, John Radcliffe Hospital, Oxford, OX3 9DS</wicri:regionArea><wicri:noRegion>OX3 9DS</wicri:noRegion></affiliation></author><author><name sortKey="Campbell, Peter J" sort="Campbell, Peter J" uniqKey="Campbell P" first="Peter J" last="Campbell">Peter J. Campbell</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA</wicri:regionArea><wicri:noRegion>CB10 1SA</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A15">Department of Haematology, Addenbrooke’s Hospital, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, Addenbrooke’s Hospital, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A16">Department of Haematology, University of Cambridge, Hills Road, Cambridge, CB2 2XY, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, University of Cambridge, Hills Road, Cambridge, CB2 2XY</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author></analytic><series><title level="j">Nature genetics</title><idno type="ISSN">1061-4036</idno><idno type="eISSN">1546-1718</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Analysis of Variance</term><term>Base Sequence</term><term>Exome (genetics)</term><term>Hemangiosarcoma (drug therapy)</term><term>Hemangiosarcoma (genetics)</term><term>Human Umbilical Vein Endothelial Cells</term><term>Humans</term><term>Molecular Sequence Data</term><term>Mutation (genetics)</term><term>Neovascularization, Pathologic (drug therapy)</term><term>Neovascularization, Pathologic (genetics)</term><term>Phospholipase C gamma (genetics)</term><term>RNA Interference</term><term>Receptor-Like Protein Tyrosine Phosphatases, Class 3 (genetics)</term><term>Sequence Analysis, RNA</term><term>Vascular Endothelial Growth Factor A (antagonists & inhibitors)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de séquence d'ARN</term><term>Analyse de variance</term><term>Cellules endothéliales de la veine ombilicale humaine</term><term>Données de séquences moléculaires</term><term>Exome (génétique)</term><term>Facteur de croissance endothéliale vasculaire de type A (antagonistes et inhibiteurs)</term><term>Humains</term><term>Hémangiosarcome (génétique)</term><term>Hémangiosarcome (traitement médicamenteux)</term><term>Interférence par ARN</term><term>Mutation (génétique)</term><term>Néovascularisation pathologique (génétique)</term><term>Néovascularisation pathologique (traitement médicamenteux)</term><term>Phospholipase C gamma (génétique)</term><term>Receptor-Like Protein Tyrosine Phosphatases, Class 3 (génétique)</term><term>Séquence nucléotidique</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Vascular Endothelial Growth Factor A</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Phospholipase C gamma</term><term>Receptor-Like Protein Tyrosine Phosphatases, Class 3</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Facteur de croissance endothéliale vasculaire de type A</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Hemangiosarcoma</term><term>Neovascularization, Pathologic</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Exome</term><term>Hemangiosarcoma</term><term>Mutation</term><term>Neovascularization, Pathologic</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Exome</term><term>Hémangiosarcome</term><term>Mutation</term><term>Néovascularisation pathologique</term><term>Phospholipase C gamma</term><term>Receptor-Like Protein Tyrosine Phosphatases, Class 3</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Hémangiosarcome</term><term>Néovascularisation pathologique</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Analysis of Variance</term><term>Base Sequence</term><term>Human Umbilical Vein Endothelial Cells</term><term>Humans</term><term>Molecular Sequence Data</term><term>RNA Interference</term><term>Sequence Analysis, RNA</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse de séquence d'ARN</term><term>Analyse de variance</term><term>Cellules endothéliales de la veine ombilicale humaine</term><term>Données de séquences moléculaires</term><term>Humains</term><term>Interférence par ARN</term><term>Séquence nucléotidique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P3">Angiosarcoma is an aggressive malignancy that arises spontaneously or secondarily to ionising radiation or chronic lymphoedema<sup><xref rid="R1" ref-type="bibr">1</xref></sup>. Previous work has identified aberrant angiogenesis, including occasional somatic mutations in angiogenesis signalling genes, as a key driver of angiosarcoma<sup><xref rid="R1" ref-type="bibr">1</xref></sup>. Here, we employed whole genome, exome, and targeted sequencing to study the somatic changes underpinning primary and secondary angiosarcoma. We identified recurrent mutations in two genes, <italic>PTPRB</italic> and <italic>PLCG1</italic>, which are intimately linked to angiogenesis. The endothelial phosphatase PTPRB, a negative regulator of vascular growth factor tyrosine kinases, harboured predominantly truncating mutations in 10/39 (26%) tumours. PLCG1, a signal transducer of tyrosine kinases, presented with a recurrent, likely activating R707Q missense variant in 3/34 cases (9%). Overall, 15/39 (38%) tumours harboured at least one driver mutation in angiogenesis signalling genes. Our findings inform and reinforce current therapeutic efforts to target angiogenesis signalling in angiosarcoma.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Young, Rj" uniqKey="Young R">RJ Young</name></author><author><name sortKey="Brown, Nj" uniqKey="Brown N">NJ Brown</name></author><author><name sortKey="Reed, Mw" uniqKey="Reed M">MW Reed</name></author><author><name sortKey="Hughes, D" uniqKey="Hughes D">D Hughes</name></author><author><name sortKey="Woll, Pj" uniqKey="Woll P">PJ Woll</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fachinger, G" uniqKey="Fachinger G">G Fachinger</name></author><author><name sortKey="Deutsch, U" uniqKey="Deutsch U">U Deutsch</name></author><author><name sortKey="Risau, W" uniqKey="Risau W">W Risau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Winderlich, M" uniqKey="Winderlich M">M Winderlich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bamford, S" uniqKey="Bamford S">S Bamford</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guo, T" uniqKey="Guo T">T Guo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dominguez, Mg" uniqKey="Dominguez M">MG Dominguez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baumer, S" uniqKey="Baumer S">S Baumer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Broermann, A" uniqKey="Broermann A">A Broermann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carra, S" uniqKey="Carra S">S Carra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hayashi, M" uniqKey="Hayashi M">M Hayashi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Z" uniqKey="Li Z">Z Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mellberg, S" uniqKey="Mellberg S">S Mellberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nawroth, R" uniqKey="Nawroth R">R Nawroth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nottebaum, Af" uniqKey="Nottebaum A">AF Nottebaum</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saharinen, P" uniqKey="Saharinen P">P Saharinen</name></author><author><name sortKey="Eklund, L" uniqKey="Eklund L">L Eklund</name></author><author><name sortKey="Pulkki, K" uniqKey="Pulkki K">K Pulkki</name></author><author><name sortKey="Bono, P" uniqKey="Bono P">P Bono</name></author><author><name sortKey="Alitalo, K" uniqKey="Alitalo K">K Alitalo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhou, Q" uniqKey="Zhou Q">Q Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Everett, Kl" uniqKey="Everett K">KL Everett</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ombrello, Mj" uniqKey="Ombrello M">MJ Ombrello</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bunney, Td" uniqKey="Bunney T">TD Bunney</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Covassin, Ld" uniqKey="Covassin L">LD Covassin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lawson, Nd" uniqKey="Lawson N">ND Lawson</name></author><author><name sortKey="Mugford, Jw" uniqKey="Mugford J">JW Mugford</name></author><author><name sortKey="Diamond, Ba" uniqKey="Diamond B">BA Diamond</name></author><author><name sortKey="Weinstein, Bm" uniqKey="Weinstein B">BM Weinstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liao, Hj" uniqKey="Liao H">HJ Liao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Antonescu, Cr" uniqKey="Antonescu C">CR Antonescu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Behjati, S" uniqKey="Behjati S">S Behjati</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tarpey, Ps" uniqKey="Tarpey P">PS Tarpey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, H" uniqKey="Li H">H Li</name></author><author><name sortKey="Durbin, R" uniqKey="Durbin R">R Durbin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ye, K" uniqKey="Ye K">K Ye</name></author><author><name sortKey="Schulz, Mh" uniqKey="Schulz M">MH Schulz</name></author><author><name sortKey="Long, Q" uniqKey="Long Q">Q Long</name></author><author><name sortKey="Apweiler, R" uniqKey="Apweiler R">R Apweiler</name></author><author><name sortKey="Ning, Z" uniqKey="Ning Z">Z Ning</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Trapnell, C" uniqKey="Trapnell C">C Trapnell</name></author><author><name sortKey="Pachter, L" uniqKey="Pachter L">L Pachter</name></author><author><name sortKey="Salzberg, Sl" uniqKey="Salzberg S">SL Salzberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Trapnell, C" uniqKey="Trapnell C">C Trapnell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Loo, P" uniqKey="Van Loo P">P Van Loo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Greenman, C" uniqKey="Greenman C">C Greenman</name></author><author><name sortKey="Wooster, R" uniqKey="Wooster R">R Wooster</name></author><author><name sortKey="Futreal, Pa" uniqKey="Futreal P">PA Futreal</name></author><author><name sortKey="Stratton, Mr" uniqKey="Stratton M">MR Stratton</name></author><author><name sortKey="Easton, Df" uniqKey="Easton D">DF Easton</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Belgique</li><li>Norvège</li><li>Royaume-Uni</li><li>Suisse</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li><li>Grand Londres</li><li>Oxfordshire</li></region><settlement><li>Cambridge</li><li>Londres</li><li>Oxford</li></settlement><orgName><li>University College de Londres</li><li>Université d'Oxford</li><li>Université de Cambridge</li></orgName></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Behjati, Sam" sort="Behjati, Sam" uniqKey="Behjati S" first="Sam" last="Behjati">Sam Behjati</name></noRegion><name sortKey="Amary, M Fernanda" sort="Amary, M Fernanda" uniqKey="Amary M" first="M Fernanda" last="Amary">M Fernanda Amary</name><name sortKey="Behjati, Sam" sort="Behjati, Sam" uniqKey="Behjati S" first="Sam" last="Behjati">Sam Behjati</name><name sortKey="Boshoff, Chris" sort="Boshoff, Chris" uniqKey="Boshoff C" first="Chris" last="Boshoff">Chris Boshoff</name><name sortKey="Bunney, Tom D" sort="Bunney, Tom D" uniqKey="Bunney T" first="Tom D" last="Bunney">Tom D. Bunney</name><name sortKey="Butler, Adam" sort="Butler, Adam" uniqKey="Butler A" first="Adam" last="Butler">Adam Butler</name><name sortKey="Campbell, Peter J" sort="Campbell, Peter J" uniqKey="Campbell P" first="Peter J" last="Campbell">Peter J. Campbell</name><name sortKey="Campbell, Peter J" sort="Campbell, Peter J" uniqKey="Campbell P" first="Peter J" last="Campbell">Peter J. Campbell</name><name sortKey="Campbell, Peter J" sort="Campbell, Peter J" uniqKey="Campbell P" first="Peter J" last="Campbell">Peter J. Campbell</name><name sortKey="Cooke, Susanna L" sort="Cooke, Susanna L" uniqKey="Cooke S" first="Susanna L" last="Cooke">Susanna L. Cooke</name><name sortKey="Flanagan, Adrienne M" sort="Flanagan, Adrienne M" uniqKey="Flanagan A" first="Adrienne M" last="Flanagan">Adrienne M. Flanagan</name><name sortKey="Flanagan, Adrienne M" sort="Flanagan, Adrienne M" uniqKey="Flanagan A" first="Adrienne M" last="Flanagan">Adrienne M. Flanagan</name><name sortKey="Futreal, P Andrew" sort="Futreal, P Andrew" uniqKey="Futreal P" first="P Andrew" last="Futreal">P Andrew Futreal</name><name sortKey="Gundem, Gunes" sort="Gundem, Gunes" uniqKey="Gundem G" first="Gunes" last="Gundem">Gunes Gundem</name><name sortKey="Halai, Dina" sort="Halai, Dina" uniqKey="Halai D" first="Dina" last="Halai">Dina Halai</name><name sortKey="Hardy, Claire" sort="Hardy, Claire" uniqKey="Hardy C" first="Claire" last="Hardy">Claire Hardy</name><name sortKey="Harris, Adrian" sort="Harris, Adrian" uniqKey="Harris A" first="Adrian" last="Harris">Adrian Harris</name><name sortKey="Harris, Adrian" sort="Harris, Adrian" uniqKey="Harris A" first="Adrian" last="Harris">Adrian Harris</name><name sortKey="Joseph, Olivia R" sort="Joseph, Olivia R" uniqKey="Joseph O" first="Olivia R" last="Joseph">Olivia R. Joseph</name><name sortKey="Katan, Matilda" sort="Katan, Matilda" uniqKey="Katan M" first="Matilda" last="Katan">Matilda Katan</name><name sortKey="Khatri, Bhavisha" sort="Khatri, Bhavisha" uniqKey="Khatri B" first="Bhavisha" last="Khatri">Bhavisha Khatri</name><name sortKey="Koss, Hans" sort="Koss, Hans" uniqKey="Koss H" first="Hans" last="Koss">Hans Koss</name><name sortKey="Koss, Hans" sort="Koss, Hans" uniqKey="Koss H" first="Hans" last="Koss">Hans Koss</name><name sortKey="Martin, Sancha" sort="Martin, Sancha" uniqKey="Martin S" first="Sancha" last="Martin">Sancha Martin</name><name sortKey="Martincorena, Inigo" sort="Martincorena, Inigo" uniqKey="Martincorena I" first="Inigo" last="Martincorena">Inigo Martincorena</name><name sortKey="Mcdermott, Ultan" sort="Mcdermott, Ultan" uniqKey="Mcdermott U" first="Ultan" last="Mcdermott">Ultan Mcdermott</name><name sortKey="Mudie, Laura" sort="Mudie, Laura" uniqKey="Mudie L" first="Laura" last="Mudie">Laura Mudie</name><name sortKey="Papaemmanuil, Elli" sort="Papaemmanuil, Elli" uniqKey="Papaemmanuil E" first="Elli" last="Papaemmanuil">Elli Papaemmanuil</name><name sortKey="Patil, Meena" sort="Patil, Meena" uniqKey="Patil M" first="Meena" last="Patil">Meena Patil</name><name sortKey="Pillay, Nischalan" sort="Pillay, Nischalan" uniqKey="Pillay N" first="Nischalan" last="Pillay">Nischalan Pillay</name><name sortKey="Pillay, Nischalan" sort="Pillay, Nischalan" uniqKey="Pillay N" first="Nischalan" last="Pillay">Nischalan Pillay</name><name sortKey="Ramakrishna, Manasa" sort="Ramakrishna, Manasa" uniqKey="Ramakrishna M" first="Manasa" last="Ramakrishna">Manasa Ramakrishna</name><name sortKey="Roxanis, Ioannis" sort="Roxanis, Ioannis" uniqKey="Roxanis I" first="Ioannis" last="Roxanis">Ioannis Roxanis</name><name sortKey="Sheldon, Helen" sort="Sheldon, Helen" uniqKey="Sheldon H" first="Helen" last="Sheldon">Helen Sheldon</name><name sortKey="Steers, Graham" sort="Steers, Graham" uniqKey="Steers G" first="Graham" last="Steers">Graham Steers</name><name sortKey="Stratton, Michael R" sort="Stratton, Michael R" uniqKey="Stratton M" first="Michael R" last="Stratton">Michael R. Stratton</name><name sortKey="Tarpey, Patrick S" sort="Tarpey, Patrick S" uniqKey="Tarpey P" first="Patrick S" last="Tarpey">Patrick S. Tarpey</name><name sortKey="Teague, Jon W" sort="Teague, Jon W" uniqKey="Teague J" first="Jon W" last="Teague">Jon W. Teague</name><name sortKey="Tirabosco, Roberto" sort="Tirabosco, Roberto" uniqKey="Tirabosco R" first="Roberto" last="Tirabosco">Roberto Tirabosco</name><name sortKey="Van Loo, Peter" sort="Van Loo, Peter" uniqKey="Van Loo P" first="Peter" last="Van Loo">Peter Van Loo</name><name sortKey="Vollan, Hans Kristian M" sort="Vollan, Hans Kristian M" uniqKey="Vollan H" first="Hans Kristian M" last="Vollan">Hans Kristian M. Vollan</name><name sortKey="Wedge, David C" sort="Wedge, David C" uniqKey="Wedge D" first="David C" last="Wedge">David C. Wedge</name></country><country name="Belgique"><noRegion><name sortKey="Van Loo, Peter" sort="Van Loo, Peter" uniqKey="Van Loo P" first="Peter" last="Van Loo">Peter Van Loo</name></noRegion></country><country name="Norvège"><noRegion><name sortKey="Vollan, Hans Kristian M" sort="Vollan, Hans Kristian M" uniqKey="Vollan H" first="Hans Kristian M" last="Vollan">Hans Kristian M. Vollan</name></noRegion><name sortKey="Vollan, Hans Kristian M" sort="Vollan, Hans Kristian M" uniqKey="Vollan H" first="Hans Kristian M" last="Vollan">Hans Kristian M. Vollan</name></country><country name="États-Unis"><noRegion><name sortKey="Cao, Yu" sort="Cao, Yu" uniqKey="Cao Y" first="Yu" last="Cao">Yu Cao</name></noRegion><name sortKey="Al Sannaa, Ghadah A" sort="Al Sannaa, Ghadah A" uniqKey="Al Sannaa G" first="Ghadah A" last="Al Sannaa">Ghadah A. Al Sannaa</name><name sortKey="Futreal, P Andrew" sort="Futreal, P Andrew" uniqKey="Futreal P" first="P Andrew" last="Futreal">P Andrew Futreal</name><name sortKey="Gumbs, Curtis" sort="Gumbs, Curtis" uniqKey="Gumbs C" first="Curtis" last="Gumbs">Curtis Gumbs</name><name sortKey="Ingram, Davis" sort="Ingram, Davis" uniqKey="Ingram D" first="Davis" last="Ingram">Davis Ingram</name><name sortKey="Lazar, Alexander J" sort="Lazar, Alexander J" uniqKey="Lazar A" first="Alexander J" last="Lazar">Alexander J. Lazar</name><name sortKey="Little, Latasha" sort="Little, Latasha" uniqKey="Little L" first="Latasha" last="Little">Latasha Little</name><name sortKey="Mahadeshwar, Harshad" sort="Mahadeshwar, Harshad" uniqKey="Mahadeshwar H" first="Harshad" last="Mahadeshwar">Harshad Mahadeshwar</name><name sortKey="Protopopov, Alexei" sort="Protopopov, Alexei" uniqKey="Protopopov A" first="Alexei" last="Protopopov">Alexei Protopopov</name><name sortKey="Ravi, Vinod" sort="Ravi, Vinod" uniqKey="Ravi V" first="Vinod" last="Ravi">Vinod Ravi</name><name sortKey="Seth, Sahil" sort="Seth, Sahil" uniqKey="Seth S" first="Sahil" last="Seth">Sahil Seth</name><name sortKey="Song, Xingzhi" sort="Song, Xingzhi" uniqKey="Song X" first="Xingzhi" last="Song">Xingzhi Song</name><name sortKey="Tang, Jiabin" sort="Tang, Jiabin" uniqKey="Tang J" first="Jiabin" last="Tang">Jiabin Tang</name><name sortKey="Torres, Keila E" sort="Torres, Keila E" uniqKey="Torres K" first="Keila E" last="Torres">Keila E. Torres</name><name sortKey="Zhang, Jianhua" sort="Zhang, Jianhua" uniqKey="Zhang J" first="Jianhua" last="Zhang">Jianhua Zhang</name></country><country name="Suisse"><noRegion><name sortKey="Baumhoer, Daniel" sort="Baumhoer, Daniel" uniqKey="Baumhoer D" first="Daniel" last="Baumhoer">Daniel Baumhoer</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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